UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9Y653
Entry Name

AGRG1_HUMAN
Protein Name

Adhesion G-protein coupled receptor G1
Primary Gene Name

ADGRG1
Organism

Homo sapiens (Human)
Molecular Function

Developmental protein
G-protein coupled receptor
Receptor
Transducer
Heparin-binding
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name G-protein coupled receptor 56 precursor(GPR56)
Cell Type
Substrate Description adhesion-class G protein-coupled receptor , multiple roles in in human physiology/pathology
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase (unkown)
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers the shed GPR56 receptor is able to interact with multiple protein ligands, suggestive of novel cellular functions such as cell adhesion and/or activation
Cleavage Information NONE
PMID 25437104



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 402
Transmembrane
 		403 423
Transmembrane
 		449 469
Extracellular
 		470 476
Transmembrane
 		477 497
Transmembrane
 		519 539
Extracellular
 		540 576
Transmembrane
 		577 597
Transmembrane
 		610 630
Extracellular
 		631 636
Transmembrane
 		637 657



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS TTLF*LLSL 12 matrix metallopeptidase-2 not physiologically relevant Mass spectroscopy 18500335   
MEROPS GAHG*RGHR 25 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER CNHL*TYFA 382 metalloproteinase 15576472    25437104   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(oral cancer ) 21714544
HCSD cancer(Liver metastasis in colorectal cancer) 23443137