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| UniProt ID |
Q9Y624 |
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| Entry Name |
JAM1_HUMAN |
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| Protein Name |
Junctional adhesion molecule A |
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| Primary Gene Name |
F11R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Host cell receptor for virus entry |
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| Membrane Location |
Cell membrane |
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| Substrate Name | JAM-A (F11R) | |
| Cell Type | endothelial cells | |
| Substrate Description | Leukocyte Recruitment, cell transmigration | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cell adhesion molecule | |
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | soluble JAM-A and LFA-1 antagonist, reduced leukocyte transmigration and recruitment into inflamed tissue | |
| Cleavage Information | NONE | |
| PMID | 18951988 |
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Start | End |
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28 | 238 |
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239 | 259 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | LALG*SVTV | 27 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LALG*SVTV | 27 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LALG*SVTV | 27 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| MEROPS | LALG*SVTV | 27 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 12665801 | ||
| MEROPS | CSEQ*DGSP | 156 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | EQDG*SPPS | 158 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | EQDG*SPPS | 158 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | SPPS*EYTW | 162 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | TWFK*DGIV | 168 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | LVFD*PLSA | 200 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TSNA*VRME | 226 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM10,ADAM17 | NONE | NONE | 19258599 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |