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|---|---|---|
| UniProt ID |
Q9Y5Y7 |
|
| Entry Name |
LYVE1_HUMAN |
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| Protein Name |
Lymphatic vessel endothelial hyaluronic acid receptor 1 |
|
| Primary Gene Name |
LYVE1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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|---|
| Substrate Name | Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), | |
| Cell Type | ||
| Substrate Description | lymphatic vessel markers in the skin. ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | ectodomain shedding of LYVE-1 occurred in lymphatic vessels undergoing chronic inflammation and might be involved in promoting pathological lymphangiogenesis. | |
| Cleavage Information | NONE | |
| PMID | 26966180 |
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|---|---|---|
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Start | End |
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20 | 238 |
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239 | 259 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | F---E (region) | 226 | ADAM17 | mutation | 26966180 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |