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| UniProt ID |
Q9Y5Y6 |
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| Entry Name |
ST14_HUMAN |
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| Protein Name |
Suppressor of tumorigenicity 14 protein |
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| Primary Gene Name |
ST14 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Membrane |
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| Substrate Name | Matriptase | |
| Cell Type | ||
| Substrate Description | degrades extracellular matrix. proposed to play a role in breast cancer invasion and metastasis. | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | protease (serine peptidase) | |
| Short Summary of Papers | activation of matriptase on epithelial cell surfaces is followed by ectodomain shedding of both matriptase and its Kunitz-type inhibitor | |
| Cleavage Information | NONE | |
| PMID | 11231297 |
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Start | End |
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56 | 76 |
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77 | 855 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | FSEG*SVIA | 149 | 12738778 | |||||
| MEROPS | RSLK*SFVV | 189 | unknown peptidase | physiologically relevant | N-terminal sequencing | 11231297 | ||
| PAPER | RSLK*SFVV | 189 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | TDSK*TVQR | 204 | unknown peptidase | physiologically relevant | N-terminal sequencing | 11231297 | ||
| MEROPS | WVCD*SVND | 509 | caspase-1 | not physiologically relevant | Mass spectroscopy | 20173201 | ||
| MEROPS | RQAR*VVGG | 614 | matriptase | physiologically relevant | NONE | 17131055 | ||
| PMAP | RQAR*VVGG | 614 | NONE | This entry is based on an experiment | 12738778 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |