UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9Y5Q5
Entry Name

CORIN_HUMAN
Protein Name

Atrial natriuretic peptide-converting enzyme
Primary Gene Name

CORIN
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Serine protease
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name corin
Cell Type HEK 293 cells (Human Embryonic Kidney 293 cells), HL-1 cardiomyocytes
Substrate Description cardiac membrane protease that activates natriuretic peptides
Substrate Function Category enzyme
Substrate Function Subtype enzyme (serine peptidase)
Sheddase ADAM, corin
Shedding-related Disease protease (serine peptidase)
Short Summary of Papers ADAM-mediated shedding and corin autocleavage are important mechanisms regulating corin function and preventing excessive, potentially hazardous, proteolytic activities in the heart.
Cleavage Information NONE
PMID 21288900



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		46 66
Extracellular
 		67 1042



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS SVVR*NMEM 164 corin physiologically relevant N-terminal sequencing 21288900   
MEROPS GDQR*CLYN 427 corin physiologically relevant N-terminal sequencing 21288900   
PAPER no_information ADAM physiologically relevant 21288900   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16878292