UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9Y287
Entry Name

ITM2B_HUMAN
Protein Name

Integral membrane protein 2B
Primary Gene Name

ITM2B
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Integral membrane protein 2B (Bri2)
Cell Type
Substrate Description beta-amyloid A4 precursor protein (APP) processing regulation
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Integral membrane protein
Sheddase ADAM10, SPPL2a/SPPL2b proteases
Shedding-related Disease Integral membrane protein
Short Summary of Papers releases soluble BRICHOS domain into the extracellular space., followed by RIP (regulated intramembrane proteolysis)
Cleavage Information NONE
PMID 21170088



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		55 75



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER APAA*LYQT 110 UNKNOWN Mass spectrometry 33796845   
MEROPS IQKR*EASN 243 furin physiologically relevant N-terminal sequencing NONE   
PAPER No_information ADAM10,SPPL2a/SPPL2b proteases 21170088   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16948836
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD non-small cell lung cancer 21262398