UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9WU39
Entry Name

SCNNG_MOUSE
Protein Name

Amiloride-sensitive sodium channel subunit gamma
Primary Gene Name

Scnn1g
Organism

Mus musculus (Mouse)
Molecular Function

Ion channel
Sodium channel
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name epithelial sodium channel (ENaC) gamma subunit
Cell Type
Substrate Description electrodiffusion of the luminal sodium and water, electrolyte and blood pressure homeostasis
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase furin
Shedding-related Disease ion channel
Short Summary of Papers furin-mediated proteolysis on the extracellular domain of ENaC γ subunit module sodium channel activation
Cleavage Information ZNo-Human:
PMID 15007080 18650438



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		56 76
Extracellular
 		77 547
Transmembrane
 		548 568



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS RKRR*EAGS 143 furin physiologically relevant mutation 15007080   
PMAP RKRR*EAGS 143 furin This_entry_is_based_on_an_experiment. Mutagenesis 18650438    15466477   
MEROPS RKRK*ISGK 186 prostasin physiologically relevant NONE 17199078   
PMAP RKRK*ISGK 186 prostasin This_entry_is_based_on_an_experiment. Others 18650438   
MEROPS IIHK*ASNV 194 plasmin physiologically relevant NONE 18981180   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825