UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9UP52
Entry Name

TFR2_HUMAN
Protein Name

Transferrin receptor protein 2
Primary Gene Name

TFR2
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Transferrin receptor-2 (TFR2)
Cell Type
Substrate Description cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Substrate Function Category blood and homoeostasis
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease iron homeostasis
Short Summary of Papers soluble form of transferrin receptor-2 (TFR2) released from the cell membrane in iron deficiency via shedding.
Cleavage Information NONE
PMID 25637053



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		84 104
Extracellular
 		105 801



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 25637053   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Urine 16948836