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| UniProt ID |
Q9UNN8 |
|
| Entry Name |
EPCR_HUMAN |
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| Protein Name |
Endothelial protein C receptor |
|
| Primary Gene Name |
PROCR |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Receptor |
|
| Membrane Location |
Membrane |
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|---|
| Substrate Name | endothelial protein C receptor (EPCR) | |
| Cell Type | ||
| Substrate Description | coagulation and inflammation | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | cell receptor (EPCR) | |
| Short Summary of Papers | soluble protein (sEPCR) inhibits the function of protein C and its activated form (APC) through competition with APC/PC binding on membrane-associated EPCR | |
| Cleavage Information | NONE | |
| PMID | 23774263 |
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Start | End |
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18 | 210 |
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211 | 231 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | WAFC*SQDA | 17 | signal peptidase complex (animal) | physiologically relevant | Mass spectroscopy | NONE | ||
| PAPER | LQSY*LLQF | 89 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | LTIR*CFLG | 113 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | IRCF*LGCE | 115 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | LREF*LEDT | 181 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | YVQK*HISA | 192 | myeloblastin | physiologically relevant | Mass spectroscopy | 17459006 | ||
| PAPER | No_information | ADAM17 | 23774263 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 15048996 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |