UniProt Summary
UniProt ID

Q9UNN8

Entry Name

EPCR_HUMAN

Protein Name

Endothelial protein C receptor

Primary Gene Name

PROCR

Organism

Homo sapiens (Human)

Molecular Function

Receptor

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name endothelial protein C receptor (EPCR)
Cell Type
Substrate Description coagulation and inflammation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease cell receptor (EPCR)
Short Summary of Papers soluble protein (sEPCR) inhibits the function of protein C and its activated form (APC) through competition with APC/PC binding on membrane-associated EPCR
Cleavage Information NONE
PMID 23774263



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
18 210
Transmembrane
211 231



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS WAFC*SQDA 17 signal peptidase complex (animal) physiologically relevant Mass spectroscopy NONE   
PAPER LQSY*LLQF 89 UNKNOWN Mass spectrometry 33796845   
PAPER LTIR*CFLG 113 UNKNOWN Mass spectrometry 33796845   
PAPER IRCF*LGCE 115 UNKNOWN Mass spectrometry 33796845   
PAPER LREF*LEDT 181 UNKNOWN Mass spectrometry 33796845   
MEROPS YVQK*HISA 192 myeloblastin physiologically relevant Mass spectroscopy 17459006   
PAPER No_information ADAM17 23774263   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Urine 17022654
Sys-BodyFluid Urine 11680902
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 15048996
Sys-BodyFluid Urine 16281181
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646
HCSD cancer(lung adenocarcinoma) 22896658
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(oral cancer ) 21714544
HCSD cancer(gastric cancer) 22204653
HCSD cancer(Lung adenocarcinoma) 22985211
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD non-small cell lung cancer 21262398
HCSD cancer(non small cell lung cancer) 19655816
HCSD cancer(colorectal cancer) 24681409
HCSD cancer(colorectal cancer) 25216327