UniProt Summary
UniProt ID

Q9UN71

Entry Name

PCDGG_HUMAN

Protein Name

Protocadherin gamma-B4

Primary Gene Name

PCDHGB4

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name protocadherin gamma-B4 (Pcdhγ)
Cell Type Human neuronal H4 cells,mouse embryonic fibroblasts
Substrate Description neuron (survival and synaptogenesis)
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule
Short Summary of Papers Pcdh-γ shedding in neuronal cell lines and primary neurons, implied a potential role in synaptic plasticity.
Cleavage Information NONE
PMID 19049889 16751190



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
31 689
Transmembrane
690 710



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PALC*EQIR unknown peptidase physiologically relevant Mass spectroscopy 26796116   
PAPER No_information ADAM10 Gel electrophoresis 16751190   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA