UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9UN70
Entry Name

PCDGK_HUMAN
Protein Name

Protocadherin gamma-C3
Primary Gene Name

PCDHGC3
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name protocadherin gamma-C3 (Pcdhγ)
Cell Type Human neuronal H4 cells,mouse embryonic fibroblasts
Substrate Description neuron (survival and synaptogenesis)
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule
Short Summary of Papers Pcdh-γ shedding in neuronal cell lines and primary neurons, implied a potential role in synaptic plasticity.
Cleavage Information NONE
PMID 19049889 16751190



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 693
Transmembrane
 		694 714



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
ASCENT LNKA*STVI 29 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT LNKA*STVI 29 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER GSAP*REQK 683 UNKNOWN Mass spectrometry 33796845   
PAPER No_information ADAM10 Gel electrophoresis 16751190   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 17081049
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646