UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9UMD9
Entry Name

COHA1_HUMAN
Protein Name

Collagen alpha-1(XVII) chain
Primary Gene Name

COL17A1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane
Secreted
Basement membrane



Biological Literature Report of Shedding
Substrate Name Collagen XVII
Cell Type HaCaT cells, COS-7 cells
Substrate Description cell adhesion, motility, development
Substrate Function Category cell surface structure
Substrate Function Subtype extracellular matrix components;
Sheddase ADAM17
Shedding-related Disease hemidesmosome (cell junction)
Short Summary of Papers shedding of collagen XVII facilitates release of the cell from its binding partners in the microenvironment, regulation of epithelial cell adhesion, detachment, and motility during development
Cleavage Information NONE
PMID 17545155



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		468 488
Extracellular
 		489 1497



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PMAP DKIG*LHSD 539 ADAM17 peptidase This entry is based on an experiment Gel electrophoresis 17545155   
PAPER No_information ADAM9,ADAM10,ADAM17 12356719   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16047308
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(colorectal cancer 24418523
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(breast cancer) 24505115
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 22623176
HCSD cancer(oral cancer ) 21714544
HCSD cancer(Lung adenocarcinoma) 22985211
HCSD cancer(Liver metastasis in colorectal cancer) 23443137