UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9UM47
Entry Name

NOTC3_HUMAN
Protein Name

Neurogenic locus notch homolog protein 3
Primary Gene Name

NOTCH3
Organism

Homo sapiens (Human)
Molecular Function

Activator
Developmental protein
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Notch3
Cell Type
Substrate Description cell fate and development
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; receptor
Sheddase ADAM10
Shedding-related Disease cell receptor
Short Summary of Papers ectodomain shedding result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes
Cleavage Information NONE
PMID 24842903



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		40 1643
Transmembrane
 		1644 1664



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD PLRD*VRGE 1628 11518718   
HPRD LVLG*VMVA 1661 11518718   
PAPER No_information ADAM10 24842903   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 16083276
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Plasma/Serum 15822942
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 22408128
HCSD cancer(ovarian cancer) 23805888
HCSD non-small cell lung cancer 21262398