UniProt Summary
UniProt ID

Q9UKQ2

Entry Name

ADA28_HUMAN

Protein Name

Disintegrin and metalloproteinase domain-containing protein 28

Primary Gene Name

ADAM28

Organism

Homo sapiens (Human)

Molecular Function

Hydrolase
Protease
Metalloprotease

Membrane Location

Secreted
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name ADAM28
Cell Type
Substrate Description diverse cellular process regulated by proteolytic cleavage
Substrate Function Category enzyme
Substrate Function Subtype enzyme (protease)
Sheddase ADAM28
Shedding-related Disease protease (metalloproteinase)
Short Summary of Papers autolytic processing of ADAM28 for proteolytic activity
Cleavage Information NONE
PMID 15013428 26554003 23643150



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
199 665
Transmembrane
666 686



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS KLKD*RKVQ 196 matrix metallopeptidase-7 physiologically relevant N-terminal sequencing 15013428   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16047308
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 16083276