UniProt Summary
UniProt ID

Q9UIK5

Entry Name

TEFF2_HUMAN

Protein Name

Tomoregulin-2

Primary Gene Name

TMEFF2

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Secreted
Membrane




Biological Literature Report of Shedding
Substrate Name TMEFF2
Cell Type
Substrate Description prostate cancer-specific cell surface marker
Substrate Function Category disease
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease cancer (prostate cancer)
Short Summary of Papers TMEFF2 contributes to cell proliferation in an ADAM17-dependent autocrine fashion
Cleavage Information NONE
PMID 17942404



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
41 320
Transmembrane
321 341



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS KLAA*FPTS 40 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PMAP No_information ADAM17 peptidase This entry is based on an experiment Others 17942404   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Plasma/Serum 12917320