UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9UHX3
Entry Name

AGRE2_HUMAN
Protein Name

Adhesion G protein-coupled receptor E2
Primary Gene Name

ADGRE2
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Adhesion G Protein-Coupled Receptor A2(ADGRE2)
Cell Type
Substrate Description adhesion-class G protein-coupled receptor, binds to the chondroitin sulfate moiety of glycosaminoglycan chains
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers shedding producing an extracellular subunit that noncovalently binds a transmembrane subunit
Cleavage Information NONE
PMID 16982628 12860403



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		24 540
Transmembrane
 		541 561
Transmembrane
 		570 590
Extracellular
 		591 605
Transmembrane
 		606 626
Transmembrane
 		645 665
Extracellular
 		666 683
Transmembrane
 		684 704
Transmembrane
 		736 756
Extracellular
 		757 760
Transmembrane
 		761 781



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD CTHL*SSFA 517 12860403   
HPRD CTHL*SSFA 517 12860403   
HPRD CTHL*SSFA 517 12860403   
HPRD CTHL*SSFA 517 12860403   
HPRD CTHL*SSFA 517 12860403   
HPRD CTHL*SSFA 517 12860403   
HPRD CTHL*SSFA 517 12860403   
MEROPS CTHL*SSFA 517 unknown peptidase physiologically relevant NONE 15150276   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Urine 16948836