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| UniProt ID |
Q9UEF7 |
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| Entry Name |
KLOT_HUMAN |
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| Protein Name |
Klotho |
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| Primary Gene Name |
KL |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Secreted |
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| Substrate Name | Klotho | |
| Cell Type | COS-7 cells | |
| Substrate Description | anti-aging regulation | |
| Substrate Function Category | ageing | |
| Substrate Function Subtype | ageing | |
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | ||
| Short Summary of Papers | release soluble form of KL from cell membrane, the remain membrane-bound fragment is subjective to intramembrane proteolysis by gamma-secretase | |
| Cleavage Information | NONE | |
| PMID | 25110992 19737556 |
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Start | End |
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34 | 981 |
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982 | 1002 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | GPET*LERF | 958 | ADAM10,ADAM17 | mutation | 25110992 | |||
| PAPER | EEFT*VCTE | 968 | ADAM10,ADAM17 | mutation | 25110992 | |||
| PAPER | No_information | ADAM10,ADAM17 | Gel electrophoresis | 19737556 | ||||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | Gel electrophoresis | 18056631 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Gel electrophoresis | 18056631 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| locate | 17986452 | ||