UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9R0T4
Entry Name

CADH1_RAT
Protein Name

Cadherin-1
Primary Gene Name

Cdh1
Organism

Rattus norvegicus (Rat)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name E-cadherin
Cell Type human keratinocyte cell line HaCaT
Substrate Description cell adehison, cell migration, cell proliferation (epithelial)
Substrate Function Category development (proliferation, differentiation)
Substrate Function Subtype cell adhesion molecule
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule
Short Summary of Papers release of the extracellular domain for the regulation of cell adhesion, cell migration and cell signalling
Cleavage Information NONE
PMID 19049889
Substrate Name E-cadherin
Cell Type HEK 293 cells (Human Embryonic Kidney 293 cells)
Substrate Description cancer cell invasion, malignant progression
Substrate Function Category disease
Substrate Function Subtype Disease: Cancers (invasion)
Sheddase ADAM17
Shedding-related Disease cancer (invasion,breast,prostate,gastric carcinoma.)
Short Summary of Papers cleavage of E-cadherin results in the release of soluble fragments of the extracellular domain and increased invasive behavior of cells
Cleavage Information NONE
PMID 22936788 25967040 24712279



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		24 713
Transmembrane
 		714 734



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS ENEV*GARI 393 elastase-2 physiologically relevant NONE 16230078   
PMAP No_information membrane-type matrix metallopeptidase-1 This_entry_is_based_on_an_experiment. Others 16077081   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825