UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9QUM0
Entry Name

ITA2B_MOUSE
Protein Name

Integrin alpha-IIb
Primary Gene Name

Itga2b
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Integrin
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name integrin alphaIIbbeta3
Cell Type platelets
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase Unknown
Shedding-related Disease B-cell chronic lymphocytic leukemia (B-CLL), thrombus
Short Summary of Papers drug ibrutinib induces shedding of integrin alphaIIbbeta3, which reduces thrombus formation
Cleavage Information
PMID 31869418



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 988
Transmembrane
 		989 1014



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA