UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9QUK6
Entry Name

TLR4_MOUSE
Protein Name

Toll-like receptor 4
Primary Gene Name

Tlr4
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Toll-like receptor 4(TLR4)
Cell Type
Substrate Description innate immune response. immune response against pathogens through recognition of molecular patterns specific to microorganisms.
Substrate Function Category disease
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease acute renal failure (ARF)
Short Summary of Papers TLR4 is shed from proximal tubules (PT) as part of the acute injury response, resulting in relative TLR4 depletion
Cleavage Information ZNo-Human:
PMID 16885150



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 638
Transmembrane
 		639 659



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 16885150   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825