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| UniProt ID |
Q9NZV1 |
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| Entry Name |
CRIM1_HUMAN |
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| Protein Name |
Cysteine-rich motor neuron 1 protein |
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| Primary Gene Name |
CRIM1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | CRIM1 | |
| Cell Type | ||
| Substrate Description | CNS development, interacte with growth factors implicated in motor neuron differentiation and survival (bind to BMP) | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | (unkown) | |
| Shedding-related Disease | growth factor binding protein | |
| Short Summary of Papers | Crim1 is subject to a juxtamembrane cleavage that generates a secreted ectodomain that binds BMPs | |
| Cleavage Information | NONE | |
| PMID | 12805376 25453556 |
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Start | End |
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35 | 939 |
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940 | 960 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GTRA*LVCL | 34 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| PAPER | GTRA*LVCL | 34 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | (unkown) | 12805376 | |||||
| PMAP | No_information | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Mass spectrometry | 18505826 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |