UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9NZU0
Entry Name

FLRT3_HUMAN
Protein Name

Leucine-rich repeat transmembrane protein FLRT3
Primary Gene Name

FLRT3
Organism

Homo sapiens (Human)
Molecular Function

Developmental protein
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name FLRT3
Cell Type
Substrate Description cell adhesion, cell migration and axon guidance
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase metalloprotease
Shedding-related Disease cell adhesion molecule
Short Summary of Papers FLRT2/3 are shed from neurons and act as repulsive guidance molecules for axons and somata of Unc5-positive neurons.
Cleavage Information NONE
PMID 21673655



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		29 528
Transmembrane
 		529 549



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER TTLN*REQE 514 UNKNOWN Mass spectrometry 33796845   
PAPER No_information metalloprotease 21673655   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Tear 16335950
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(ovarian cancer) 23805888
HCSD non-small cell lung cancer 21262398