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|---|---|---|
| UniProt ID |
Q9NZR2 |
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| Entry Name |
LRP1B_HUMAN |
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| Protein Name |
Low-density lipoprotein receptor-related protein 1B |
|
| Primary Gene Name |
LRP1B |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | lipoprotein receptor related protein 1B (LRP1B) | |
| Cell Type | ||
| Substrate Description | endocytic receptor,receptor-mediated endocytosis. | |
| Substrate Function Category | lipid (lipoprotein receptor famiy) | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | the tumor suppression function of LRP1B is mediated by proteolytic processing of the LRP1B and subsequently ICD release,(RIP (regulated intramembrane proteolysis); ECDs of LRP1b may modulate cellular signaling by scavenging and neutralizing extracellular ligands | |
| Cleavage Information | NONE | |
| PMID | 17227771 |
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Start | End |
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25 | 4444 |
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4445 | 4467 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | ARPC*KKDE | 3762 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | ACSN*KKCI | 3771 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| PAPER | REKR*QANS | 3957 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | K | 4432 | metalloproteinase | mutagenesis | 17227771 | |||
| PAPER | K | 4435 | metalloproteinase | mutagenesis | 17227771 | |||
| PAPER | R | 4442 | metalloproteinase | mutagenesis | 17227771 | |||