UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9NZQ7
Entry Name

PD1L1_HUMAN
Protein Name

Programmed cell death 1 ligand 1
Primary Gene Name

CD274
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Programmed death-ligand 1 (PD-L1)
Cell Type breast cancer cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM10 and/or ADAM17
Shedding-related Disease breast cancer
Short Summary of Papers First investigation of proteolytic cleavage of PD-L1 by ADAM10/ADAM17 in breasst cancer cell.
Cleavage Information
PMID 31796994
Substrate Name Programmed death-ligand 1 (PD-L1)
Cell Type T-cell and macrophages
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase Unknown
Shedding-related Disease lymphoma
Short Summary of Papers patients with high-level expression for soluble form of PD-L1 showed worse prognosis than low-level group
Cleavage Information
PMID 28349165



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 238
Transmembrane
 		239 259



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LLNA*FTVT 18 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA