UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9NZC2
Entry Name

TREM2_HUMAN
Protein Name

Triggering receptor expressed on myeloid cells 2
Primary Gene Name

TREM2
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name TREM2
Cell Type
Substrate Description chronic inflammations. stimulate production of chemokines and cytokines.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM/MMP
Shedding-related Disease cell receptor
Short Summary of Papers TREM2 undergoes sequential proteolytic processing by ectodomain shedding and RIP (regulated intramembrane proteolysis), the intramembranous proteolysis of TREM2 may functionally link two Alzheimer disease-associated proteins in one signaling pathway,
Cleavage Information NONE
PMID 24078628



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 174
Transmembrane
 		175 195



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM/MMP 24078628   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825