UniProt Summary
UniProt ID

Q9NT68

Entry Name

TEN2_HUMAN

Protein Name

Teneurin-2

Primary Gene Name

TENM2

Organism

Homo sapiens (Human)

Molecular Function

Repressor

Membrane Location

Postsynaptic cell membrane
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name Teneurin-2
Cell Type HEK293A and NB2a
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase (probably) furin
Shedding-related Disease
Short Summary of Papers Released ectodomain of Teneurin-2 binds latrophilin-1, which activates intracellular calcium signaling
Cleavage Information
PMID 27499734



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Transmembrane
380 400
Extracellular
401 2774



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS RERR*SIQT 528 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16104056
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456