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| UniProt ID |
Q9NR96 |
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| Entry Name |
TLR9_HUMAN |
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| Protein Name |
Toll-like receptor 9 |
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| Primary Gene Name |
TLR9 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | Toll-like receptor 9(TLR9) | |
| Cell Type | ||
| Substrate Description | TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | cathepsin S | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | ectodomain cleavage of TLR9 represents a strategy to restrict receptor activation to endolysosomal compartments and prevent TLRs from responding to self nucleic acid.; proteolytic processing mechanism negatively regulates TLR9 signaling | |
| Cleavage Information | NONE | |
| PMID | 18820679 21604257 |
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Start | End |
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26 | 818 |
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819 | 839 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | FSKA*KELR | 724 | cathepsin S | 21604257 | ||||
| PAPER | NALK*TV | 738 | cathepsin S | 21604257 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |