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|---|---|---|
| UniProt ID |
Q9NPG4 |
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| Entry Name |
PCD12_HUMAN |
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| Protein Name |
Protocadherin-12 |
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| Primary Gene Name |
PCDH12 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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|---|
| Substrate Name | Protocadherin12 (PCDH12) | |
| Cell Type | ||
| Substrate Description | cell interactions at interendothelial junctions, homotypic calcium-dependent aggregation and adhesion, may play an important role in placental development | |
| Substrate Function Category | development (placental) | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | protocadherin-12 undergo cleavage by ADAM10 and γ-secretase (regulated intramembrane proteolysis) sequentially, circulating PCDH12 is increase in pregnant women | |
| Cleavage Information | NONE | |
| PMID | 21402705 |
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Start | End |
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25 | 718 |
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719 | 739 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | ADAM10 | 21402705 | |||||