UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9NP99
Entry Name

TREM1_HUMAN
Protein Name

Triggering receptor expressed on myeloid cells 1
Primary Gene Name

TREM1
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name TREM1
Cell Type
Substrate Description leukocyte activation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; receptor (Triggering receptor expressed on myeloid cells )
Sheddase metalloproteinase
Shedding-related Disease cell receptor
Short Summary of Papers release of soluble form sTREM-1, the up-regulated level of sTREM-1 is suggested correlated with sepsis and infectious diseases
Cleavage Information NONE
PMID 17785845



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 205
Transmembrane
 		206 226



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloprotease 17785845   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
HCSD cancer(Glioblastoma) 23483059