UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9JI18
Entry Name

LRP1B_MOUSE
Protein Name

Low-density lipoprotein receptor-related protein 1B
Primary Gene Name

Lrp1b
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name lipoprotein receptor related protein 1B (LRP1B)
Cell Type
Substrate Description endocytic receptor,receptor-mediated endocytosis.
Substrate Function Category lipid (lipoprotein receptor famiy)
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell receptor
Short Summary of Papers the tumor suppression function of LRP1B is mediated by proteolytic processing of the LRP1B and subsequently ICD release,(RIP (regulated intramembrane proteolysis); ECDs of LRP1b may modulate cellular signaling by scavenging and neutralizing extracellular ligands
Cleavage Information NONE
PMID 17227771



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 4444
Transmembrane
 		4445 4467



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloproteinase 17227771   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825