UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9JHJ8
Entry Name

ICOSL_MOUSE
Protein Name

ICOS ligand
Primary Gene Name

Icoslg
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name ICOSL
Cell Type T follicular helper and TH2 cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease allergic airway disease
Short Summary of Papers ADAM10 is the physiological relevant sheddase of ICOSL.
Cleavage Information
PMID 28814605



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		47 277
Transmembrane
 		278 298



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS AASA*ETEV 46 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825