UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9HDB5
Entry Name

NRX3B_HUMAN
Protein Name

Neurexin-3-beta
Primary Gene Name

NRXN3
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name neurexin-3beta
Cell Type
Substrate Description neuronal cell surface protein that may be involved in cell recognition and cell adhesion
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease cell adhesion molecule
Short Summary of Papers two final fragement cleaved from α- and γ-secretases(extracellular domain (sNRXN3β) and intracellular NRXN3β domain (NRXN3β-ICD)), may potentially implicated in the regulation of NRXNs and neuroligins functions at the synapses
Cleavage Information NONE
PMID 17901375



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		36 562
Transmembrane
 		563 583



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS ETSR*TTTT 465 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS ETSR*TTTT 465 LAST_MAM peptidase (Limulus-type) not physiologically relevant Mass spectroscopy 21693781   
PAPER No_information ADAM17 17901375   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Cerebrospinal fluid 17853512
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(ovarian cancer) 23805888