UniProt Summary
UniProt ID

Q9HBJ8

Entry Name

CLTRN_HUMAN

Protein Name

Collectrin

Primary Gene Name

CLTRN

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name pancreatic β-cell surface protein (Tmem27)
Cell Type
Substrate Description stimulator of beta cell replication,may regulate β -cell proliferation and insulin secretion
Substrate Function Category insulin
Substrate Function Subtype
Sheddase Bace2
Shedding-related Disease cell surface protein
Short Summary of Papers membrane-bound form of Tmem27 stimulates β cells replication whereas soluble form of Tmem27 failed to perform same biological results.
Cleavage Information NONE
PMID 22628310 16330324



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
15 141
Transmembrane
142 162



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER NNAF*FLND 116 Bace2 22628310   
PAPER AFFL*NDQT 118 Bace2 22628310   
PAPER TLEF*LKIP 125 Bace2 22628310   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16948836