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| UniProt ID |
Q9HAV5 |
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| Entry Name |
TNR27_HUMAN |
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| Protein Name |
Tumor necrosis factor receptor superfamily member 27 |
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| Primary Gene Name |
EDA2R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Membrane |
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| Substrate Name | X-linked ectodermal dysplasia receptor (XEDAR,TNFRSF27) | |
| Cell Type | ||
| Substrate Description | receptor for EDA isoform A2. mediates the activation of the NF-kappa-B and JNK pathways. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | extracellular domain of XEDAR undergoes cleavage by metalloproteinase and generated a soluble 20-kDa fragment. the binding of EDA-A2 to XEDAR blocked the proteolytic processing of XEDAR and subsequently suppressed cell growth. | |
| Cleavage Information | NONE | |
| PMID | 20501644 |
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Start | End |
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1 | 138 |
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139 | 159 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | Q-L | 121 | metalloproteinase | mutation | 20501644 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |