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| UniProt ID |
Q9H5V8 |
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| Entry Name |
CDCP1_HUMAN |
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| Protein Name |
CUB domain-containing protein 1 |
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| Primary Gene Name |
CDCP1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) | |
| Cell Type | PC-3 (human prostate cancer cell lines) | |
| Substrate Description | dysregulated processing and disease progression | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers | |
| Sheddase | type II transmembrane serine protease (TTSP) matriptase | |
| Shedding-related Disease | cancer | |
| Short Summary of Papers | shedding of CDCP1 ectodomain, results in tyrosine phosphorylation of cell-retained CDCP1 fragment and recruitment of Src and PKCĪ“ | |
| Cleavage Information | NONE | |
| PMID | 20551327 |
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Start | End |
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30 | 667 |
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668 | 688 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GAEA*FEIA | 29 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 12660814 | ||
| HPRD | KQSR*KFVP | 368 | Matriptase | 16007225 | ||||
| MEROPS | KQSR*KFVP | 368 | matriptase | physiologically relevant | NONE | 16007225 | ||
| PAPER | KQSR*KFVP | 368 | type II transmembrane serine protease (TTSP) matriptase | 20551327 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Urine | 16807940 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |