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|---|---|---|
| UniProt ID |
Q9H4D0 |
|
| Entry Name |
CSTN2_HUMAN |
|
| Protein Name |
Calsyntenin-2 |
|
| Primary Gene Name |
CLSTN2 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function | ||
| Membrane Location |
Cell membrane |
|
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|---|
| Substrate Name | Alcadein(Alc-gamma) | |
| Cell Type | ||
| Substrate Description | cargo-receptor for the kinesin-1 motor that mediates anterograde transport of APP | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | Alzheimer Disease | |
| Short Summary of Papers | small Peptides p3-Alcs were generated via the cleavage of Alcadeins were cleavages by ADAM10/17 and γ-Secretases(regulated intramembrane proteolysis) sequentially. the alterations of C termini of p3-Alcs may indicate Alzheimer Disease-related γ-Secretase Dysfunction | |
| Cleavage Information | NONE | |
| PMID | 19864413 |
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|---|---|---|
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Start | End |
|
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21 | 831 |
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832 | 852 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | HVNH*LIVQ | 803 | ADAM10 peptidase | physiologically relevant | Mass spectroscopy | 19864413 | ||
| MEROPS | HVNH*LIVQ | 803 | ADAM17 peptidase | physiologically relevant | Mass spectroscopy | 19864413 | ||
| MEROPS | SIAT*VVII | 834 | ADAM10 peptidase | physiologically relevant | Mass spectroscopy | 19864413 | ||
| MEROPS | SIAT*VVII | 834 | ADAM17 peptidase | physiologically relevant | Mass spectroscopy | 19864413 | ||
| MEROPS | TVVI*IISV | 837 | ADAM10 peptidase | physiologically relevant | Mass spectroscopy | 19864413 | ||
| MEROPS | TVVI*IISV | 837 | ADAM17 peptidase | physiologically relevant | Mass spectroscopy | 19864413 | ||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |