UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9H2A7
Entry Name

CXL16_HUMAN
Protein Name

C-X-C motif chemokine 16
Primary Gene Name

CXCL16
Organism

Homo sapiens (Human)
Molecular Function

Cytokine
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CXCL16
Cell Type endothelial cell, monocytes
Substrate Description Leukocyte Recruitment, Chemokine recruitment of leukocytes, Firm adhesion and locomotion to the endothelial cell junction
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine
Sheddase ADAM10
Shedding-related Disease cytokine
Short Summary of Papers release soluble chemokine,de-adhesion, soluble chemoattractant, decreased scavenger receptor activity, decreased endothelial
Cleavage Information NONE
PMID 16565325 23428418 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		30 205
Transmembrane
 		206 226



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
ASCENT IHTA*GHSL 175 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER No_information ADAM10 15128827   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
HCSD cancer (gastric cancer) 23161554
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD non-small cell lung cancer 21262398