UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9ERQ6
Entry Name

CSPG5_RAT
Protein Name

Chondroitin sulfate proteoglycan 5
Primary Gene Name

Cspg5
Organism

Rattus norvegicus (Rat)
Molecular Function

Developmental protein
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Chondroitin sulfate proteoglycan 5 (neuroglycan C)
Cell Type
Substrate Description may function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
Substrate Function Category cell surface structure
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease proteoglycan
Short Summary of Papers soluble form of NGC is released via proteolytic cleavage. the shedding of the NGC ectodomain may be implicated in the regulation of physiological and pathological functions of NGC in the brain.
Cleavage Information ZNo-Human:
PMID 17532789



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		31 428
Transmembrane
 		429 449



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS TAGA*VPAR 30 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 7592931   
PAPER No_information metalloproteinase 17532789   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825