UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9EQU3
Entry Name

TLR9_MOUSE
Protein Name

Toll-like receptor 9
Primary Gene Name

Tlr9
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Toll-like receptor 9(TLR9)
Cell Type
Substrate Description TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase cathepsin S
Shedding-related Disease cell receptor
Short Summary of Papers ectodomain cleavage of TLR9 represents a strategy to restrict receptor activation to endolysosomal compartments and prevent TLRs from responding to self nucleic acid.; proteolytic processing mechanism negatively regulates TLR9 signaling
Cleavage Information NONE
PMID 18820679 21604257



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 818
Transmembrane
 		819 839



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 18820679   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825