UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9DDD3
Entry Name

Q9DDD3_CHICK
Protein Name

Calsyntenin-1 protein
Primary Gene Name

calsyntenin-1
Organism

Gallus gallus (Chicken)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Calsyntenin-1(Alc-alpha)
Cell Type
Substrate Description cargo-receptor for the kinesin-1 motor that mediates anterograde transport of APP; may modulate Ca+2-mediated postsynaptic signals.
Substrate Function Category disease;central nervous system (neuron)
Substrate Function Subtype
Sheddase ADAM10, ADAM17
Shedding-related Disease Alzheimer Disease;cell surface protein
Short Summary of Papers small Peptides p3-Alcs were generated via the cleavage of Alcadeins were cleavages by ADAM10/17 and γ-Secretases(regulated intramembrane proteolysis) ; calsyntenin-1 undergoes proteolytically cleaved, and calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca+2 signaling.equentially. the alterations of C termini of p3-Alcs may indicate Alzheimer Disease-related γ-Secretase Dysfunction
Cleavage Information NONE
PMID 19864413 11161476



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		828 848



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 11161476   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA