UniProt Summary
UniProt ID

Q9C0C4

Entry Name

SEM4C_HUMAN

Protein Name

Semaphorin-4C

Primary Gene Name

SEMA4C

Organism

Homo sapiens (Human)

Molecular Function

Developmental protein

Membrane Location

Postsynaptic cell membrane
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name semaphorin 4C (Sema4C)
Cell Type human embryonic kidney (HEK) 293-FT (Invitrogen)
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease
Short Summary of Papers Type I transmembrane protein, semaphorin 4C, is cleaved and shed by BACE1.
Cleavage Information
PMID 20041192



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
21 663
Transmembrane
664 684



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS VESD*CYAE 247 unknown peptidase physiologically relevant Mass spectroscopy 16179924   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
HCSD cancer (lung cancer) 19776420
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(lung adenocarcinoma) 22896658
HCSD cancer(pancreatic cancer) 21625447