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| UniProt ID |
Q9BZR6 |
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| Entry Name |
RTN4R_HUMAN |
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| Protein Name |
Reticulon-4 receptor |
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| Primary Gene Name |
RTN4R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Nogo-66 receptor (NgR) | |
| Cell Type | ||
| Substrate Description | Receptor for RTN4, OMG and MAG, mediates activation of Rho, mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase, ADAM17 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | cleavage of NgR abrogates axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth. | |
| Cleavage Information | GPI-anchor | |
| PMID | 15331667 16849393 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | VAAP*CPGA | 26 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| ASCENT | ADKA*SVLE | 344 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | ADKA*SVLE | 344 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | metalloproteinase | 15331667 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |