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| UniProt ID |
Q9BY67 |
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| Entry Name |
CADM1_HUMAN |
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| Protein Name |
Cell adhesion molecule 1 |
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| Primary Gene Name |
CADM1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Tumor suppressor cell adhesion molecule 1 (CADM1) | |
| Cell Type | HEK293 (Human Embryonic Kidney 293 cells) , human osteosarcoma Saos-2 | |
| Substrate Description | heterophilic cell-cell adhesion. Synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly . May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | shedding of CADM1 may result in protein downregulation, and module adhesion between cells | |
| Cleavage Information | NONE | |
| PMID | 22172944 |
| Substrate Name | Tumor suppressor cell adhesion molecule 1 (CADM1) | |
| Cell Type | lung alveolar epithelial cell, islet cells | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: idiopathic interstitial pneumonia (IIP); type 2 diabetic pancreata | |
| Sheddase | metalloproteinase (suggested from cross reference) | |
| Shedding-related Disease | idiopathic interstitial pneumonia (IIP), type 2 diabetic pancreata | |
| Short Summary of Papers | increased CADM1 α-shedding contributes to AEC (Lung alveolar epithelial cell) apoptosis in emphysematous lungs; increased CADM1 ectodomain shedding, promote apoptosis of beta cells | |
| Cleavage Information | NONE | |
| PMID | 26231557 24964098 |
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Start | End |
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45 | 374 |
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375 | 395 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | GRYF*CQLY | 123 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | YFCQ*LYTD | 125 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | FCQL*YTDP | 126 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | LYTD*PPQE | 129 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | PPQE*SYTT | 133 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LMLK*VHKE | 208 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | GLTR*EGDA | 258 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | EASN*IVGK | 317 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | HSDY*MLYV | 326 | chymotrypsin A (cattle-type) | not physiologically relevant | Mass spectroscopy | 18500335 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | ovary | 15815987 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |