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| UniProt ID |
Q9BXS0 |
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| Entry Name |
COPA1_HUMAN |
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| Protein Name |
Collagen alpha-1(XXV) chain |
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| Primary Gene Name |
COL25A1 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Heparin-binding |
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| Membrane Location |
Membrane |
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| Substrate Name | CLAC-P(collagen type XXV) | |
| Cell Type | ||
| Substrate Description | protection against proteolysis and cell toxicity of β-amyloid in AD brains. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | furin convertase | |
| Shedding-related Disease | Alzheimer Disease | |
| Short Summary of Papers | 9D2 antigen CLAC (collagen-like Alzheimer amyloid plaque component) released by furin convertase | |
| Cleavage Information | NONE | |
| PMID | 11927537 |
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|---|---|---|
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Start | End |
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34 | 54 |
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55 | 654 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RRLI*KGDQ | 187 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | PPGQ*KGSI | 244 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| PAPER | No_information | furin convertase | 1192753 | |||||