UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q9BX67
Entry Name

JAM3_HUMAN
Protein Name

Junctional adhesion molecule C
Primary Gene Name

JAM3
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Junctional adhesion molecule-C (JAM-C)
Cell Type
Substrate Description cell adhesion, leukocyte-platelet interactions, regulation of transepithelial migration of PMN, soluble form is a mediator of angiogenesis
Substrate Function Category angiogenesis
Substrate Function Subtype
Sheddase ADAM10, ADAM17
Shedding-related Disease cell adhesion molecule
Short Summary of Papers modulation of soluble form (sJAM-C) may provide a novel route for controling pathological angiogenesis
Cleavage Information NONE
PMID 20592283



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 241
Transmembrane
 		242 262



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LIGA*VNLK 31 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER No_information ADAM10,ADAM17 20592283   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119