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| UniProt ID |
Q99M75 |
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| Entry Name |
RTN4R_RAT |
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| Protein Name |
Reticulon-4 receptor |
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| Primary Gene Name |
Rtn4r |
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| Organism |
Rattus norvegicus (Rat) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Nogo-66 receptor (NgR) | |
| Cell Type | ||
| Substrate Description | Receptor for RTN4, OMG and MAG, mediates activation of Rho, mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | metalloproteinase, ADAM17 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | cleavage of NgR abrogates axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth. | |
| Cleavage Information | GPI-anchor | |
| PMID | 15331667 16849393 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | ADAM17 | 16849393 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||