UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

Q99J85
Entry Name

NPTXR_MOUSE
Protein Name

Neuronal pentraxin receptor
Primary Gene Name

Nptxr
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Neuronal pentraxin receptor (NPR)
Cell Type cleaved NPR involved in endocytosis of AMPAR (AMPA-type glutamate receptors (AMPAR))
Substrate Description synaptogenesis, synapse remodeling
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; neuronal receptors
Sheddase ADAM17
Shedding-related Disease cell receptor
Short Summary of Papers destabilize EC junctions; Increased endothelial permeability
Cleavage Information ZNo-human; O95502
PMID 18367087



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		3 23
Extracellular
 		24 493



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PARA*LPGG 35 ADAM17 peptidase physiologically relevant NONE 18367087   
MEROPS DTMA*DGAW 175 ADAM17 peptidase physiologically relevant NONE 18367087   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825