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| UniProt ID |
Q99523 |
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| Entry Name |
SORT_HUMAN |
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| Protein Name |
Sortilin |
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| Primary Gene Name |
SORT1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Sortilin (SORT1) | |
| Cell Type | (CHO) Chinese hamster ovary cell | |
| Substrate Description | hormone signaling | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | neuronal receptors | |
| Sheddase | ADAM17, ADAM10 | |
| Shedding-related Disease | cell receptor (VPS10 domain) | |
| Short Summary of Papers | shed versions of sorCS receptors may have wider functions as growth factor-binding proteins that with ligand binding capability; sortilin ectodomain shedding acts as a regulatory switch for delivery of BDNF to the secretory pathway | |
| Cleavage Information | NONE | |
| PMID | 16393139 21730062 |
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Start | End |
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78 | 755 |
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756 | 778 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | LRAA*AAGG | 63 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | RWRR*SAPG | 77 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | LSPE*KQNS | 748 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM17 | 16393139 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |