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| UniProt ID |
Q99497 |
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| Entry Name |
PARK7_HUMAN |
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| Protein Name |
Parkinson disease protein 7 |
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| Primary Gene Name |
PARK7 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | protein deglycase DJ-1 (PARK7) | |
| Cell Type | ||
| Substrate Description | protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. | |
| Substrate Function Category | enzyme;disease | |
| Substrate Function Subtype | ||
| Sheddase | MMP3 | |
| Shedding-related Disease | deglycase;Parkinson's disease | |
| Short Summary of Papers | DJ-1 is fragmented by the intracellular MMP3 in response to cell stress, abolishing the protective role of DJ-1 against oxidative damage, and this contributes to the pathogenesis of PD. | |
| Cleavage Information | Lipid-anchor | |
| PMID | 20969476 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | ASKR*ALVI | 5 | DESC1 peptidase | not physiologically relevant | Mass spectroscopy | 25211023 | ||
| MEROPS | ASKR*ALVI | 5 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | ASKR*ALVI | 5 | matriptase | not physiologically relevant | Mass spectroscopy | 25211023 | ||
| MEROPS | SKRA*LVIL | 6 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LVIL*AKGA | 10 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | VILA*KGAE | 11 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 20526345 | ||
| MEROPS | ILAK*GAEE | 12 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 20526345 | ||
| MEROPS | ILAK*GAEE | 12 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GAEE*METV | 16 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | EEME*TVIP | 18 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DVMR*RAGI | 27 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | AGIK*VTVA | 32 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | VTVA*GLAG | 36 | cathepsin L | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | TVAG*LAGK | 37 | cathepsin B | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | TVAG*LAGK | 37 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | TVAG*LAGK | 37 | astacin | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | TVAG*LAGK | 37 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 20526345 | ||
| MEROPS | TVAG*LAGK | 37 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 18505826 | ||
| PAPER | TVAG*LAGK | 37 | MTMMP1 | 18505826 | ||||
| PMAP | TVAG*LAGK | 37 | membrane-type matrix metallopeptidase-1 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 18505826 | ||
| MEROPS | LAGK*DPVQ | 41 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | VQCS*RDVV | 47 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 20526345 | ||
| MEROPS | QCSR*DVVI | 48 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | CSRD*VVIC | 49 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DVVI*CPDA | 52 | cathepsin L | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | DVVI*CPDA | 52 | cathepsin S | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | ASLE*DAKK | 59 | glutamyl peptidase I | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | EDAK*KEGP | 62 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | DAKK*EGPY | 63 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PAPER | DAKK*EGPY | 63 | MMP3 | 20969476 | ||||
| MEROPS | EGPY*DVVV | 67 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | GPYD*VVVL | 68 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | YDVV*VLPG | 70 | elastase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | PGGN*LGAQ | 76 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GNLG*AQNL | 78 | cathepsin L | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | GAQN*LSES | 81 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GAQN*LSES | 81 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | GAQN*LSES | 81 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | QNLS*ESAA | 83 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | QNLS*ESAA | 83 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | AAVK*EILK | 89 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| PAPER | AAVK*EILK | 89 | MMP3 | 20969476 | ||||
| MEROPS | QENR*KGLI | 98 | hepsin | not physiologically relevant | Mass spectroscopy | 25211023 | ||
| MEROPS | QENR*KGLI | 98 | matriptase-2 | not physiologically relevant | Mass spectroscopy | 25211023 | ||
| MEROPS | RKGL*IAAI | 101 | chymotrypsin A (cattle-type) | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LIAA*ICAG | 104 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | AAIC*AGPT | 106 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | AICA*GPTA | 107 | LAST peptidase (Limulus-type) | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | AICA*GPTA | 107 | LAST_MAM peptidase (Limulus-type) | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | AGPT*ALL | 110 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | GPTA*LLA | 111 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | GPTA*LLA | 111 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 18505826 | ||
| PAPER | GPTA*LLAH | 111 | MTMMP1 | 18505826 | ||||
| PMAP | GPTA*LLAH | 111 | membrane-type matrix metallopeptidase-1 | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 18505826 | ||
| MEROPS | PTAL*LAHE | 112 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | TALL*AHEI | 113 | cathepsin S | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | ALLA*HEIG | 114 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | FGSK*VTTH | 122 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | LAKD*KMMN | 131 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | NRVE*KDGL | 147 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | VEKD*GLIL | 149 | caspase-6 | physiologically relevant | mutation | 19680261 | ||
| PAPER | LTSR*GPGT | 156 | MMP3 | 20969476 | ||||
| MEROPS | SFEF*ALAI | 164 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | FEFA*LAIV | 165 | RC1339 g.p. (Rickettsia conorii) | not physiologically relevant | Mass spectroscopy | 25144529 | ||
| MEROPS | EFAL*AIVE | 166 | HIV-1 retropepsin | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | IVEA*LNGK | 171 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | ALNG*KEVA | 174 | DJ-1 putative peptidase | physiologically relevant | mutation | 20304780 | ||
| MEROPS | LNGK*EVAA | 175 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | EVAA*QVKA | 179 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | VAAQ*VKAP | 180 | matrix metallopeptidase-2 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | AQVK*APLV | 182 | cathepsin L | not physiologically relevant | Mass spectroscopy | 21967108 | ||
| MEROPS | AQVK*APLV | 182 | trypsin 1 | not physiologically relevant | Mass spectroscopy | 18500335 | ||
| MEROPS | KAPL*VLKD | 185 | chymotrypsin A (cattle-type) | not physiologically relevant | Mass spectroscopy | 18500335 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 16739998 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Cerebrospinal fluid | 14998169 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 17877382 | |
| Sys-BodyFluid | Plasma/Serum | 12917320 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(lung cancer) | 21186846 | |
| HCSD | cancer(Lung adenocarcinoma) | 22985211 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |