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| UniProt ID |
Q99075 |
|
| Entry Name |
HBEGF_HUMAN |
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| Protein Name |
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor |
|
| Primary Gene Name |
HBEGF |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Growth factor |
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| Membrane Location |
Secreted |
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| Substrate Name | HB-EGF | |
| Cell Type | cardiomyocytes | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: cardiac hypertrophy | |
| Sheddase | ADAM12 | |
| Shedding-related Disease | cardiac hypertrophy | |
| Short Summary of Papers | shedding of (HB-EGF) and subsequent transactivation of the EGFR when cardiomyocytes were stimulated by GPCR agonists | |
| Cleavage Information | NONE | |
| PMID | 11786904 |
| Substrate Name | HB-EGF | |
| Cell Type | keratinocyte cell, human corneal epithelial (THCE) cells | |
| Substrate Description | Cutaneous Wound Healing (tissue repair) | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | ADAM9, ADAM10, ADAM12, ADAM17 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | wound-Induced HB-EGF Ectodomain Shedding and EGFR Activation in Corneal Epithelial Cells | |
| Cleavage Information | NONE | |
| PMID | 11038170 14985295 |
| Substrate Name | HB-EGF | |
| Cell Type | SH-SY5Y, Namalwa, CHO cells | |
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | MMP-7, ADAM17 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | conversion from juxtacrine to a paracrine/autocrine growth factor, soluble agonist of EGFR and ErbB4 | |
| Cleavage Information | NONE | |
| PMID | 11825873 18951988 |
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Start | End |
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20 | 160 |
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161 | 184 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RLRR*GLAA | 31 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| PMAP | RLRR*GLAA | 31 | ADAM17 peptidase | This entry is based on an experiment | 15066986 | |||
| MEROPS | RKVR*DLQE | 62 | furin | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKVR*DLQE | 62 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKVR*DLQE | 62 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKVR*DLQE | 62 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKVR*DLQE | 62 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKVR*DLQE | 62 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKVR*DLQE | 62 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| MEROPS | LDLL*RVTL | 72 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| MEROPS | DLLR*VTLS | 73 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| MEROPS | LSLP*VENR | 149 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 12135759 | ||
| MEROPS | LSLP*VENR | 149 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| MEROPS | LPVE*NRLY | 151 | matrix metallopeptidase-3 | physiologically relevant | NONE | 9395517 | ||
| MEROPS | LPVE*NRLY | 151 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 12135759 | ||
| MEROPS | LPVE*NRLY | 151 | membrane-type matrix metallopeptidase-4 | physiologically relevant | NONE | 12135759 | ||
| PMAP | LPVE*NRLY | 151 | matrix metallopeptidase-3 | This entry is based on an experiment | N-terminal sequencing | 9395517 | ||
| MEROPS | VENR*LYTY | 153 | membrane-type matrix metallopeptidase-4 | physiologically relevant | NONE | 12135759 | ||
| PMAP | No_information | matrix metallopeptidase-7 | This entry is based on an experiment | Others | 11825873 | |||